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RS-504393 is an extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 µM for inhibition of human recombinant CCR2b and CCR1 receptors respectively)
and Orally Bioavailable CCR2 Antagonist
CFTR(Inh)172
with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis
Smiles: [Sr+2]
SR1078 - CAS# 1246525-60-9 acapone RS-504393 is an extremely selectiveSR 1078 is a selective agonist of ROR and ROR that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 M without effect at the related liver X receptors and farnesoid X receptors. SR1078 modulates the conformation of ROR in a biochemical assay and activates ROR and ROR driven transcription. SR1078 stimulates expression of endogenous ROR target genes in HepG2 cells that express both ROR and ROR. SR1078
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