CX-5461 - RNA Polymerase I inhibitor. CAS# 1138549-36-6 0179 5]oxadiazol-5-amine

5]oxadiazol-5-amine

pp 130–134

56(19):7498-500

31)/b23-22-

KY02111 was used at 10 µM final concentration in vitro and in cellular assays

CX-5461 - RNA Polymerase I inhibitor. CAS# 1138549-36-6 0179 5]oxadiazol-5-amineCX 5461, CAS No. 1138549 36 6, is a first in class non genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX 5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal